Prolonged Hyperoxygenation Treatment Improves Vein Graft Patency and Decreases Macrophage Content in Atherosclerotic Lesions in ApoE3*Leiden Mice.

Il6 mRNA expression was studied as a representative for ROS induced factors and quantification of its expression showed a trend towards increased expression in the carbogen group of the chronic exposure study when compared to the control group ( Figure 6 A, p -value = 0.09).

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Despite the beneficial effects of the hyperoxygenation treatment on vein grafts, i.e., improved vein graft patency and a strong trend towards an increased plaque stability index, chronic hyperoxygenation also induced Hif1a mRNA expression, ROS accumulation and apoptosis.

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