Isoform-resolved correlation analysis between mRNA abundance regulation and protein level degradation.

While biological processes such as “mRNA splicing” and “translation” showed a significant trend toward positive correlation (median ρ = 0.283 and 0.336, P < 0.0001), “protein catabolic process” and “establishment of protein localization” represent GOBPs in which mRNA and k loss tend to anti‐correlate (median ρ = −0.325 and −0.168, P < 0.02).

also in 9,775 other papers

The protein degradation carries a clear trend to buffer transcript variation for large mitoribosome subunit (median ρ = 0.532, mRNA– k loss correlation), but not for the small one (median ρ = −0.014, Wilcoxon test, P = 0.0022, Fig 5 J).

also in 19,460 other papers