Barely Significant
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A comprehensive analysis of methods for assessing polygenic burden on Alzheimer's disease pathology and risk beyond <i>APOE</i>.

Brain Commun · 2020 · PMC7100005 · PMID 32226939

Europe PMCDOI
2
hedged sentences
0.0440
closest p · 0.9× alpha
0.0900
boldest claim

The sentences

nominally significantP = 0.044actually significant
After adjusting for age, sex, years of education and APOE -ε4 carrier status, PHS (status) showed a strong association in all three contrasts involving CN subjects ( P ≤ 4.32e-06), while there was only a nominally significant effect between MCI and Alzheimer’s disease ( P = 0.044; Table 2 ).

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showed a trendP = 0.09so close (0.05 < p ≤ 0.1)
When adjusting for APOE -ε4 status in the Cox regression, PHS (status) showed a significant effect on clinical progression ( P = 0.002), with higher polygenic hazard increasing the risk of conversion, while APOE -ε4 burden showed a trend over APOE -ε4 status ( P = 0.09).

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.