Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth.

Food intake of Nsun5 knockout mice (mean = 3.53 g/day) was slightly reduced compared to wildtype animals (mean = 3.75 g/day), but did not reach statistical significance (Figure 2G ).

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Interestingly, quantification of OPP incorporation into liver, kidney, lung and bone marrow also showed a trend towards decreased protein synthesis in Nsun5 knockout animals compared to littermate controls (Figure 6H ), but to a lesser extent then in MEFs.

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