Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease.

In this study, there was a strong trend towards a reduced corpus callosum volume in Hu128/21 compared to Hu21 saline treated animals at 7 months of age but this did not reach statistical significance (Figure 5C , unpaired t -test between Hu21 and Hu128/21 saline treated P = 0.0623).

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There was a trend towards an increase in time spent in the centre of the field for Hu128/21 mice as a result of treatment but this failed to reach significance (Mixed-effects model for all Hu128/21 treated groups at both timepoints; treatment P = 0.2820, time P < 0.0001, treatment × time P = 0.0365).

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In this study, there was a strong trend towards a reduction in striatal volume in saline treated Hu128/21 compared to Hu21 mice at 7 months post-injection, however this did not reach significance (Figure 5A , Unpaired t-test between Hu21 and Hu128/21 saline treated P = 0.052).

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