103 , 104 , 105 , 106 , 107 Patients with ALI/ARDS receiving treatment with a statin during admission had a 73% lower odds of death, although this failed to reach statistical significance (odds ratio, 0.27; 95% confidence interval, 0.06 to 1.21; P = .09). 108 In contrast, another study suggested no benefit. 109 A recent study has shown pretreatment with a statin 110 reduces pulmonary markers of inflammation in an inhaled LPS-induced model of lung injury in healthy volunteers.
2
0.0900
0.0900
The sentences
In a large sepsis study of 448 patients, ibuprofen diminished prostanoid production and was associated with a trend toward decreased duration of pulmonary dysfunction and ARDS, but this did not reach statistical significance. 81 Modulation of other inflammatory mediators has also been investigated, but to date, no treatment has been shown to effectively reduce mortality.