Induction of tryptophan hydroxylase in the liver of s.c. tumor model of prostate cancer.

Plasma Kyn (Figure 2 B) and 5‐ HTP (Figure 2 C) levels tended to be lower in AT‐2 engrafted rats compared to control, but did not reach statistical significance at any time point.

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The Kyn / Trp ratio showed a trend to increase and 5‐HTP / Trp ratio increased significantly in AT‐2 engrafted rats compared to control (Figure 2 D,E). 3.2 Tryptophan, kynurenine, and serotonin levels in tissues We next quantified levels of Trp, Kyn, and serotonin in several tissues, including liver, small intestine (jejunum and ileum), immune tissues (spleen and thymus), and tumor.

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