Smooth muscle specific WNT5A overexpression showed a clear trend towards enhanced actin (α-SMA) expression in the ASM in ovalbumin challenged animals, but had no effect on collagen content.
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Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation.
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The sentences
WNT5A showed a trend towards increased airway smooth muscle thickness in allergen challenged animals but did not regulate deposition of extracellular matrix components.