In this study we were able to show that two haplotypes (GAGTAG in haploblock 2 and CAACCGGG in haploblock 3) were associated with reduced CRYBB2 mRNA expression in lymphocytes, while one haplotype (TAC in haploblock 4) showed a trend ( p < 0.1), which is why these three haplotype blocks were selected for further analysis.
For the two haplotypes associated with antisaccade performance, suggestive evidence was found with visual memory and in addition, haplotype block 4 showed a nominally significant association with reduced sensorimotor gating, measured as P50 ratio.
For this purpose, an fMRI working memory task (N-back task) was performed, in which we demonstrated a significantly higher activation within the group of carriers of the risk haplotypes of block 2 and 3, which was replicated in both, patients and healthy controls, with highly significant results in the combined group.