An Individual Participant Data Population Pharmacokinetic Meta-analysis of Drug-Drug Interactions between Lumefantrine and Commonly Used Antiretroviral Treatment.

Finally, a negative trend between bioavailability and milligrams per kilogram of dose was detected in the ART-naive arms of SEACAT, InterACT, and for the AL-only arm of Uganda clinical study 1.

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The HIV-positive (HIV + ) but ART-naive participants from the SEACAT (South East African Combination Anti-malarial Therapy) study showed a trend toward moderately increased clearance of lumefantrine, but the same trend was not found with the HIV + ART-naive participants in the other studies.

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