A novel targeted RNA-Seq panel identifies a subset of adult patients with acute lymphoblastic leukemia with BCR-ABL1-like characteristics.

Due to the limited number of BCR-ABL1 -like patients in our series, the difference in CR achievement between BCR-ABL1 -like and non- BCR-ABL1 -like patients did not reach statistical significance, although there were four times as many patients not achieving CR in the BCR-ABL1 -like subgroup.

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However, these differences showed a trend for DFS and were not statistically significant for CIR, in which patients with CDKN2A/B loss had higher relapse incidence in both subgroups individually.

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