Barely Significant
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A common polymorphism in the mechanosensitive ion channel <i>PIEZO1</i> is associated with protection from severe malaria in humans.

Proc Natl Acad Sci U S A · 2020 · PMC7183233 · PMID 32265284

Europe PMCDOI
2
hedged sentences
0.0600
closest p · 1.2× alpha
0.0600
boldest claim

The sentences

failed to reach statistical significanceP = 0.06so close (0.05 < p ≤ 0.1)
For subjects with HbAS, homozygosity for E756del (DEL/DEL) was associated with an elevated risk of severe malaria compared to those with E756 WT/WT or WT/DEL, though this failed to reach statistical significance ( P = 0.06 and 0.07, respectively).

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did not reach statistical significanceno p-value reported
While this association was based on few data points and did not reach statistical significance, it highlights the need for further research on the interplay between these genes, as it suggests that the protective effect of HbAS on malaria may be subverted by structural or permeability abnormalities associated with the homozygous E756del genotype.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.