The SQSTM1-NUP214 fusion protein interacts with Crm1, activates Hoxa and Meis1 genes, and drives leukemogenesis in mice.

PLoS One · 2020 · PMC7188244 · PMID 32343715

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showed a trendno p-value reported

Compared with SQSTM1-NUP214, the binding of SQSTM1-NUP214 FGmut showed a trend toward lower binding across all genes but the difference was not statistically significant.

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did not reach statistical significanceno p-value reported

Whereas the reduction in binding of SQSTM1-NUP214 to chromatin caused by LMB was only on the order of 10–20% and did not reach statistical significance, LMB lowered the binding of SQSTM1-NUP214 FGmut to Hoxa and Meis1 chromatin by 25 to 50% ( Fig 4C and 4D ).

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