Targeting Vascular Calcification in Chronic Kidney Disease.

At follow-up, there was a smaller numerical increase (i.e., attenuation of progression) in the CAC score of the cinacalcet-treated patients compared with those treated with flexible vitamin D therapy; however, this did not reach statistical significance (progression of CAC: 24%; 95% CI: −22% to 119% vs. 31% (95% CI: −9% to 179%; p = 0.073).

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After a median follow-up of 17 (placebo) to 21 (cinacalcet) months, there was an observed trend for relative reduction in the HR for the primary composite CV outcome (i.e., time until death, myocardial infarction, hospitalization for unstable angina, heart failure, or a peripheral vascular event) (HR: 0.93; 95% CI: 0.85 to 1.02; p = 0.11).

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Post hoc adjustment for age yielded lower relative HRs with nominally significant results in favor of cinacalcet, as did the analyses that accounted for differential withdrawal of study drug and commercial use of cinacalcet in the placebo arm.

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