Replication analysis of variants associated with multiple sclerosis risk.

Sci Rep · 2020 · PMC7193640 · PMID 32355262

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did not reach statistical significanceno p-value reported

Therefore, it is probable that due to the low representation of MS cases with younger age of MS onset in our replication MS cohort (17% with MS age of onset ≤20 years) rs1800693 association with MS risk did not reach statistical significance following adjustment for multiple testing.

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nominally significantno p-value reported

These variants included; Ecotropic Viral Integration Site 5 ( EVI5 ) rs11808092 (OR: 2.04, 95%CI: 1.4–2.9), TNF Receptor Superfamily Member 1 A ( TNFRSF1A ) rs1800693 (OR: 2.01, 95%CI: 1.45–2.75), Lymphocyte Function-Associated Antigen 3 ( CD58 ) rs1414273 (OR: 2.2, 95%CI: 1.5–3.2), and a nominally significant and not clearly robust Methylenetetrahydrofolate Reductase ( MTHFR ) variant rs1801131 (OR: 1.4, 95%CI: 1.02–1.9).

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