Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7.

Elife · 2020 · PMC7200161 · PMID 32366358

Europe PMC DOI

hedged sentences

0.0770

closest p · 1.5× alpha

0.0780

boldest claim

The sentences

did not reach statistical significancep=0.077so close (0.05 < p ≤ 0.1)

Total iBAT lysates from Ucp1 CRE : Alk7 fx/fx conditional mutant mice showed increased ATGL levels compared to controls ( Figure 2C ), although the difference did not reach statistical significance (p=0.077).

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a strong trendp=0.078so close (0.05 < p ≤ 0.1)

Enhanced ATGL protein levels in the mutants were accompanied by a strong trend (p=0.078) towards increased Atgl mRNA levels after fasting ( Figure 2D ). iBAT from fasted conditional mutant mice also showed a significant decrease in the mRNA levels of G0/G1 switch gene 2 ( G0S2 ), which encodes an inhibitor of ATGL activity ( Yang et al., 2010 ; Figure 2E ).

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