Trauma induced clotting factor depletion in severely injured children: a single center observational study.

Finally, the median activity of FVIII showed a considerable increase in both patient cohorts (SI 235 [91-320] % and MI 197 [164-238] %, respectively) compared with the CO, but although a strong trend was identified between the SI and CO (108 [89-133] %; p = 0.17), no significant differences were detected.

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Although there was an obvious trend in SI children towards a decrease in the median activity of FVII (71 [63-97] %) and FX (70 [61-85] %), this did not reach statistical significance when compared with the MI cohort (FVII 89 [75-107] %; p = 0.16 and FX 79 [65-115] %; p = 0.33).

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