2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference.

CONCLUSIONS: This exploratory analysis showed a trend toward increased hypertension, inflammatory and respiratory comorbidity, higher RVS, and previous corticosteroid treatment in patients initiating on IG compared with all PID patients.

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Immune laboratory studies included: normal newborn Trec screening; normal IgG at 12 weeks (76 mg/dL), and borderline low T and B cells at 5, 9, and 12 weeks (PMIDs 31220471, 27548364) with an increasing trend (CD4+ T cells: 944 -> 965-> 1581; CD8+ T cells: 396 -> 519 -> 737; B cells: 234 -> 878 -> 1358).

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TNFα, IFNy, IL-10, and IL-17A expression in patients with CGD who had active colitis or history of colitis were increased as compared to CGD patients without a history of colitis but did not reach statistical significance.

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