Protein-altering germline mutations implicate novel genes related to lung cancer development.

Nat Commun · 2020 · PMC7214407 · PMID 32393777

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0900

boldest claim

The sentences

highly significantP = 1.18 × 10 −15actually significant

Results for lung cancer overall are less significant after PC adjustment, but there is still a highly significant result for the ATM −2307F association in LUAD ( P = 1.18 × 10 −15 for discovery and P = 2.22 × 10 −3 for replication (Table 1 ).

also in 132,142 other papers

a significant trendP = 0.06so close (0.05 < p ≤ 0.1)

The variant rs150665432 showed a significant trend ( P = 0.06) in the much smaller replication dataset.

also in 9,775 other papers

borderline significanceP = 0.09so close (0.05 < p ≤ 0.1)

For female lung AD, this effect was most pronounced in the discovery dataset (69.37 ± 10.71 vs 62.78 ± 11.06, P = 0.0007) and showed borderline significance in the replication dataset (68.74 ± 10.49 vs 63.69 ± 10.31, P = 0.09, Supplementary Table 13 and Fig. 4a ).

also in 7,017 other papers

weakly significantno p-value reported

Among males, L2307F showed a weakly significant association with lung cancer risk in the discovery dataset and no association in the replication dataset (Fig. 2a and Supplementary Table 5 ).

also in 1,387 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.