Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity.

Congruent with these data, we observed apparently augmented incorporation of labelled glucose into glycogen, although this failed to reach statistical significance (Fig. 5d , p = 0.064) and significantly increased skeletal muscle glycogen content in DMPP-treated mice, also compared with pair-fed mice with a similar loss in body weight (Fig. 5e, f , p ≤ 0.05).

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In support of this notion, muscle glycogen content was increased and glucose incorporation into glycogen in chronic DMPP-treated DIO WT mice was augmented; however this difference did not reach statistical significance.

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