Beneficial Effects of Acetyl-DL-Leucine (ADLL) in a Mouse Model of Sandhoff Disease.

J Clin Med · 2020 · PMC7230825 · PMID 32276303

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did not reach statistical significanceno p-value reported

However, their levels, as well as the p -mTOR: total mTOR ratio did not reach statistical significance when compared to Hexb -/- untreated mice ( Figure 2 a,b).

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failed to reach statistical significanceno p-value reported

Therefore, although there was a trend towards BCKADH activation with ADLL treatment, indicating enhanced ADLL catabolism, it failed to reach statistical significance.

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