Partial reduction of amyloid β production by β-secretase inhibitors does not decrease synaptic transmission.

Inhibition of γ-secretase using LY411575 decreased secretion of both Aβ40 and Aβ42 equally at all three doses, although the decrease of Aβ42 did not reach statistical significance.

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LY2886721 treatment also showed a trend towards decreased secretion of Aβ42 with 37% at 0.04 μM and with 43% at 0.3 μM and significantly decreased Aβ42 with 57% at 3 μM (Fig. 2 b (II)).

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