Beneficial metabolic role of β-arrestin-1 expressed by AgRP neurons.

Similarly, the HFD AgRP-barr1-KO mice showed a strong trend toward increased HGP during the hyperinsulinemic clamp (steady-state conditions; 90 to 120 min) ( P = 0.053; Fig. 2D ), consistent with hepatic insulin resistance.

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Phosphorylation of hormone-sensitive lipase (HSL) was also increased in WAT derived from the barr1 mutant mice, although this effect failed to reach statistical significance (fig.

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