Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation.

For both cell lines bafilomycin A1 treatment did not affect LC3A-II levels, while a trend towards increasing LC3B-II levels after treatment was observed, though this did not reach statistical significance (p = 0.061 for untreated vs. treated control neurons; p = 0.057 for untreated vs. treated PARK2 KO neurons) (Fig. 6A,D,E ).

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The number of cells did not change significantly over time upon CCCP treatment, however, there was a clear trend towards a decreased number of cells after 72 and 96 hrs of exposure (Supp.

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