Similar results were reported in the J-RHYTHM registry sub-analysis, which showed a trend towards increasing rates of major hemorrhage with decreasing BMI, but that being underweight was not associated with a significantly increased risk of hemorrhage compared with patients of normal weight [ 6 ].
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Impact of body mass index on real-world outcomes of rivaroxaban treatment in Japanese patients with non-valvular atrial fibrillation.
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This result is consistent with a community-based cohort study targeting Japanese patients over 80 years old, in that mortality from cardiovascular disorders, cancer, or pneumonia tended to be highest in the underweight group compared with other groups, even though the differences did not reach statistical significance [ 28 ].