Association Study of Coronary Artery Disease-Associated Genome-Wide Significant SNPs with Coronary Stenosis in Pakistani Population.

Interestingly, two SNPs ( SORT1 /rs602633, UBE2Z /rs46522) including the one that showed a trend of association in the additive model became significant ( p < 0.05) and two ( COL4A1-COL4A2 /rs4773144, CYP17A1-CNNM2-NT5C2 /rs12413409) showed a trend of association ( p < 0.10) ( Table 3 ).

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Logistic regression analysis under the additive genetic model (Table S2 ) revealed 3 nominally significant SNPs with p < 0.05 ( PLG /rs4252120, KIAA1462 /rs2505083, and SLC22A3-LPAL2-LPA /rs2048327) and 2 SNPs showing a trend for association with p < 0.10 ( SORT1 /rs602633 and SMG6 /rs2281727) ( Table 2 ).

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