We found that inactivation of Prdm1 in Hdac3- KO CD8 T cells showed a trend toward improved persistence compared with Hdac3- WT CD8 T cells, but this effect did not reach statistical significance in all experiments (pooled data shown in Fig. 7 C ).
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Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells.
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