Epigenome-450K-wide methylation signatures of active cigarette smoking: The Young Finns Study.

There were 26602 nominally significant ( P -value < 0.05) CpG sites ( Figure 1 ).

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It is noteworthy that the genes related to olfactory system did not reach statistical significance threshold in the gene level differential methylation analysis, while their co-occurrence as a gene set (on pathway level) passes statistical significance threshold.

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