Association analysis of polymorphisms rs12997 in ACVR1 and rs1043784 in BMP6 genes involved in bone morphogenic protein signaling pathway in primary angle-closure and pseudoexfoliation glaucoma patients of Saudi origin.

Analysis of rs12997 in PXG patients showed a trend towards association as compared to controls (Table 4 ) with G/G genotype resulting in a 2-fold increased of disease ( p = 0.049) in co-dominant model.

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In PXG, the rs12997[G/G] genotype showed a significant trend towards increased risk of the disease (OR = 2.04, 95% CI = 0.99–4.18, p = 0.049) but did not survive the Bonferroni correction.

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