Liver Stiffness Hinders Normalization of Systemic Inflammation and Endothelial Activation after Hepatitis C Virus (HCV) Eradication in HIV/HCV Coinfected Patients.

Vaccines (Basel) · 2020 · PMC7350227 · PMID 32575428

Europe PMC DOI

hedged sentences

0.0670

closest p · 1.3× alpha

0.1300

boldest claim

The sentences

a clear trendp = 0.067so close (0.05 < p ≤ 0.1)

Moreover, the pair-wise comparison (Mann-Whitney U test) showed significantly higher levels in pre-DAAs HIV/HCV compared to the HIV group for IL-18 ( p = 0.008), IP-10 ( p < 0.0001) and VCAM-1 ( p < 0.0001) with a clear trend for ICAM-1 ( p = 0.067).

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showed a trendp = 0.13not close (p > 0.1)

At this time-point, levels of IL-18 and ICAM-1 in the post-DAAs HIV/HCV group were comparable to those observed in the HIV group and in HC donors, whereas VCAM-1 levels remained significantly increased in the post-DAAs HIV/HCV group compared to HC donors ( p = 0.006 for the global comparison and p = 0.001 for the pair-wise comparison between the post-DAAs HIV/HCV group and HC donors), and levels of IP-10 showed a trend ( p = 0.13 for the global comparison and p = 0.07 for the pair-wise comparison between the post-DAAs HIV/VCV group and HC donors) ( Figure 3 ).

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