Tract-specific analysis improves sensitivity of spinal cord diffusion MRI to cross-sectional and longitudinal changes in amyotrophic lateral sclerosis.

In our longitudinal study, we found consistent changes in RD and MD, and a parallel trend in AD that did not reach statistical significance, in the whole cord aand in individual tracts, in ALS subjects.

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We also noted a clear trend in the group difference in FA in the posterior column, with a well separated group mean throughout C2–C6, but this difference was not statistically significant due to the large within-group variance.

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