A Novel Sulfonamide, 4-FS, Reduces Ethanol Drinking and Physical Withdrawal Associated With Ethanol Dependence.

4-FS did not significantly alter the amount of ethanol consumed or active lever responses in CIE-ED rats, however, showed a strong trend towards decrease compared with vehicle treatment (ethanol intake: p = 0.06; active lever responses: p = 0.08). 4-FS reduced inactive lever responses in CIE-ED and ED rats (CIE-ED: p = 0.04; ED: p = 0.01; Figure 5 c). 4-FS did not alter lever responses during timeout in CIE-ED and ED rats (CIE-ED: p = 0.06; ED: p = 0.13; Figure 5 d). 2.5. 4-FS Alters Expression of GluRs and GABA A Rs in the Ventral Hippocampus Protein expression between vehicle controls and 4-FS treated controls did not differ and therefore they were combined as controls and used for analyses.

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4-FS also demonstrated a strong trend towards reduction in drinking in CIE-ED rats, although this effect did not reach statistical significance.

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