Circulating miRNAs in Small Extracellular Vesicles Secreted by a Human Melanoma Xenograft in Mouse Brains.

Moreover, three of them showed a trend of upregulation during disease progression from healthy controls to primary and metastatic melanoma cases. 2.

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Noticeably, even though they did not reach statistical significance (probably due to the small sample size), three out of the 20 expressed miRNAs, including one human-specific (miR-224-5p) and two conserved miRNAs (miR-130a-3p, miR-21-5p) had a trend of upregulation during melanoma progression, from healthy controls to primary melanoma and metastatic cases ( Figure 7 B). 3.

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