5-HT_2A receptor loss does not alter acute fluoxetine-induced anxiety and exhibit sex-dependent regulation of cortical immediate early gene expression.

Acute Flx treatment did not alter the mRNA expression levels of the IEGs assessed, except for a strong trend for decline observed in gene expression levels of Bdnf and Homer3 in the male PFC ( Figure 5 B).

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For the percent time spent in the open arms for males, we did note a trend toward an interaction of genotype × Flx ( F (1,50) = 3.39, P =0.0714) ( Figure 2 D), which did not reach statistical significance.

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