Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice.

Interestingly, this effect was due to the higher MPO levels seen in female mice while no gender difference was apparent in pancreatic mass, pancreatic water content and plasma amylase (Fig. 4 ).

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When compared to C57BL/6N mice, trypsin activity was about 15% higher in the pancreas of Ctrl-KO mice, although the difference did not reach statistical significance (Fig. 6 A).

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