The neural basis of hot and cold cognition in depressed patients, unaffected relatives, and low-risk healthy controls: An fMRI investigation.

There were nominally significant negative relationships between DLPFC activation and both amygdala/sgACC activation during happy emotion processing (amygdala: r =−0.246, p = 0.016; sgACC: r =−0.202, p = 0.049), such that participants with the highest DLPFC activation had the lowest amygdala and sgACC activation (see Fig. 5 ).

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For sgACC deactivation during fearful>neutral faces, neither HAM-D nor BDI scores correlated significantly with deactivation, though both showed a trend in the same direction: greater sgACC deactivation was associated with higher levels of depression (HAM-D ( r =−0.284, p = 0.080); BDI ( r =−0.302, p = 0.062)).

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