Overall genotype effects were observed for increased respiratory exchange ratio (RER; P = 0.0246; Figure 2 I) and carbohydrate oxidation ( P = 0.0376; Figure 2 K) in β1 W100A mice versus WT, while the observed trend for an overall genotype effect of decreased fat oxidation in β1 W100A versus WT mice did not reach statistical significance (P = 0.0611; Figure 2 L).
Despite an observed trend toward an overall genotype effect for reduced β1 W100A fed and fasting liver glycogen versus WT ( P = 0.1004; Figure 3 O), this did not reach statistical significance. β1 W100A mice displayed no change in maximal running speed or time to exhaustion during submaximal exercise ( Figure 3 S–T).
There was a trend toward an overall genotype and condition interaction (P = 0.0690), but this failed to reach statistical significance ( Figure 4 Q).