Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.

Though none remained significant after adjustment for multiple testing, one result was borderline significant (p=0.053) after correcting for 300 tests ( Table 1 ).

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The signal imparted by additional polygenic common variant risk, similar to previous studies using idiopathic schizophrenia case-control samples several orders of magnitude larger ( 6 , 13 ), produced clearly significant results.

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Using this best-fit liability threshold model to calculate the sample sizes required to provide 80% power to detect a nominally significant difference in PRS at pT=0.05, indicated that apart from the comparison of PRS between 22q11.2DS individuals without psychosis and WTCCC controls, all other primary analyses of polygenic risk were sufficiently powered ( Table S6 ).

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