Cumulative LBR, recorded for patients who underwent a single stimulation cycle with a single fresh or frozen blastocyst transfer within a year of treatment initiation, were similar in both groups, with a positive trend in favour of HP-hMG (40% HP-hMG vs 38% rFSH beta).
← all excerpts
Influence of human chorionic gonadotrophin during ovarian stimulation: an overview.
3
—
—
The sentences
However, evidence to the contrary was provided by the PERSIST and ESPART trials, which indicated that rFSH alfa/rLH treatment is neither equivalent nor superior to rFSH alfa monotherapy for the number of oocytes retrieved, OPR or LBR, with the latter two outcomes displaying a negative trend instead.
In the MEGASET trial, HP-hMG also showed a trend towards a lower incidence of early ovarian hyperstimulation syndrome (OHSS) and/or safety interventions due to excessive ovarian response compared with rFSH beta ( P = 0.025) [ 108 ].