C3, C5a and anti-acetylcholine receptor antibody as severity biomarkers in myasthenia gravis.

When we stratified patients according to disease duration, the subgroup with fewer than 5 years from symptoms onset showed a trend toward higher levels of C5 ( p = 0.057) and lower levels of C3 ( p = 0.06) in patients with higher clinical severity on the ADL scale.

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There was a positive correlation between AChR-ab titers and MGC and ADL severity scores ( Figure 2 ), and a strong trend towards higher titers in patients with exacerbated MG than in those with stable MG (5.9 nmol/L and 4.7 nmol/L, respectively), ( p = 0.06) ( Figure 2 ).

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