High fat-fed GPR55 null mice display impaired glucose tolerance without concomitant changes in energy balance or insulin sensitivity but are less responsive to the effects of the cannabinoids rimonabant or Δ(9)-tetrahydrocannabivarin on weight gain.

However, there was a numerical increase in energy expenditure in the wild-type (but not the knockout) mice that did not reach statistical significance, and in increase an energy expenditure was detected in our previous study ( Wargent et al., 2013a ; Wargent et al., 2013b ).

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They demonstrated more clearly significant differences between genotypes in insulin signalling in isolated liver, skeletal muscle and adipose tissues.

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