GATA-4, a potential novel therapeutic target for high-grade meningioma, regulates miR-497, a potential novel circulating biomarker for high-grade meningioma.

2 c, and Table S4) confirmed that GATA-4 is significantly overexpressed in WHO III meningioma tissues when compared to WHO I (32% increase), but the increase in expression in WHO II tumours, compared with WHO I, did not reach statistical significance.

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Both miR-497 and −195 proved to be significantly downregulated in WHO II compared to WHO I samples in both cohorts, and showed a trend to decrease in WHO III compared to WHO I samples in the discovery set.

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