Overall it seems that in acute COVID-19 infection there is a trend toward a decreased TIGIT frequency on T cells compared to healthy donors while T cells in acute malaria patients generally showed a trend toward higher TIGIT frequencies compared to healthy individuals.
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Analysis of Co-inhibitory Receptor Expression in COVID-19 Infection Compared to Acute <i>Plasmodium falciparum</i> Malaria: LAG-3 and TIM-3 Correlate With T Cell Activation and Course of Disease.
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The same trend was evident on CD8 + EM T cells although this trend did not reach statistical significance.