Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice.

Consistent with our in vitro data, expression of Pck1 was significantly attenuated by the triple HDAC knockdown ( Figure 3B ) while the downregulation of G6pc did not reach statistical significance.

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However, the calculation of the AUC did not mirror this deviation and the differences in AUC failed to reach statistical significance ( Figure 4C ).

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