Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1.

A previous western blot analysis [ 128 ] and the current study suggest that this insertional event did not significantly reduce Zbtb20 protein levels in AD-relevant brain regions of J20 mice, although J20 showed a trend toward Zbtb20 reduction in the parietal cortex that did not reach statistical significance.

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