Assessing the need for pioglitazone in the treatment of patients with type 2 diabetes: a meta-analysis of its risks and benefits from prospective trials.

4 a) In addition, there was 12% reduced odds of developing stroke, which did not reach statistical significance (95% CI 0.59–1.03).

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A quick perusal of these numbers is self-explanatory; although the risk of fractures may not be significant in clinical terms, the risk of HF is a huge concern despite a definite benefit noted in patients treated with Pio on MACE.

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Conclusion The use of Pio resulted in significant reduction in MACE, while a reduction in stroke which was seen against all comparators failed to reach statistical significance on subgroup analysis when compared to placebo.

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The odds of anaemia associated with Pio use was also highly significant.

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