Hydroxychloroquine is effective, and consistently so when provided early, for COVID-19: a systematic review.

New Microbes New Infect · 2020 · PMC7534595 · PMID 33042552

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a clear trendno p-value reported

Interestingly, none of the no-effect studies showed a clear trend towards worsening.

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did not reach statistical significanceno p-value reported

Four additional studies [ 9 , 10 , 15 , 16 ] had positive trends towards efficacy that did not reach statistical significance.

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