Entecavir vs Tenofovir in Hepatocellular Carcinoma Prevention in Chronic Hepatitis B Infection: A Systematic Review and Meta-Analysis.

Clin Transl Gastroenterol · 2020 · PMC7544163 · PMID 33031195

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did not reach statistical significanceno p-value reported

However, this beneficial effect did not reach statistical significance for noncirrhotic patients (aHR: 0.83, 95% CI: 0.51–1.35) and retrospective/prospective cohort studies using clinical records (aHR: 0.97; 95% CI: 0.80–1.18).

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showed a trendno p-value reported

Of the 8 studies reporting no significant difference, 5 actually showed a trend toward better cancer preventive effect for TDF vs ETV (Figure 2 ).

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of borderline significanceno p-value reported

We show that the beneficial effect did not exist in non-Asians and was of borderline significance for Asians.

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