Autoantibodies Toward ATP4A and ATP4B Subunits of Gastric Proton Pump H+,K+-ATPase Are Reliable Serological Pre-endoscopic Markers of Corpus Atrophic Gastritis.

The median age did not differ between cases and controls (cases: 64 years, range 18–88, vs controls: 67.5 years, range 23–90; Mann-Whitney test P = 0.46), although female sex showed a trend toward increased frequency in cases (66.4% vs 54.1%, P = 0.073).

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However, the proportion of ATP4B autoantibody–negative cases in subjects younger than 70 years of age was significantly lower than that in older individuals (31.5% vs 59.35, P = 0.009), although the overall prevalence of ATP4B autoantibodies showed a trend toward a reduction with increasing age that did not reach statistical significance ( P = 0.0952) (Figure 3 ).

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