Preoperative opioid, sedative, and antidepressant use is associated with increased postoperative hospital costs in colorectal surgery.

Surg Endosc · 2021 · PMC7545805 · PMID 33034774

Europe PMC DOI

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

ADM use also showed a trend toward increased MTHC though it did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.